Research and Publications on KCS and Cyclosporine
by RL Kaswan
DVM, MS DACVO
Funded Research Grants & Contracts
for KCS and ophthalmic cyclosporine
Epidemiologic and Etiopathogenic Studies of
Keratoconjunctivitis Sicca in the Dog.
Martin CL. Kaswan RL. Veterinary Medical Experiment Station,
$3,600, 1980.
Modulation of Experimental Immunogenic Uveitis in
Rabbits with Topically Administered Cyclosporine. Kaswan RL, Martin CL, Kaplan H.
National Society to Prevent Blindness, $9,740, 1984.
Modulation of Experimental Lens-Induced Uveitis with
Cyclosporine. Kaswan RL, Martin CL,
Kaplan H. National Eye Institute,
National Institutes of Health, $15,000, 1984.
Ocular Bioavailability of Cyclosporine in Rabbits. Kaswan RL, Martin CL, Tackett R. Veterinary Medical Experiment Station, UGA,
$10,801, 1984.
Studies on Use of Cyclosporine Ophthalmic
Preparations. Kaswan RL. Alcon Laboratories, $4,000, 1984.
Cyclosporine Therapy for Experimental Uveitis. Kaswan RL.
Veterinary Medicine Memorial Research Fund, $600, 1984.
Modulation of Experimental Lens-Induced Granulomatous
Endophthalmitis with Cyclosporine.
Kaswan RL. Hill's Pet Food,
$400, 1984.
Experimental Modulation of Lens-Induced Granulomatous
Endophthalmitis with Cyclosporine.
Kaswan RL. Sigma XI Honor
Society, $500, 1984.
Efficacy of Cyclosporine Eyedrops in Sjogren's
Syndrome. FDA Orphan Products
Development Grant. Kaswan R, Green K,
Hull D, Mondino B, Lemp M, Williamson J.
$129,199. Approved for funding,
1989, relinquished to Sandoz in license agreement.
Ocular Bioavailability of Cyclosporine in Rabbits. Kaswan RL.
Sandoz Pharmaceutical Co., Inc., $27,030, 1984-88.
License patent ophthalmic cyclosporine for human
use. Sandoz Pharmaceuticals Inc. 1989.
Ophthalmic cyclosporine for veterinary patient
use. Sublicense of patented technology
from UGARF to Schering-Plough, 1990.
Cyclosporine treatment of Ocular Disease. Kaswan RL.
Sandoz Research Institute $141,750.
1989-1992, Research grant.
Research Grants Approved, not funded:
The Immunopathology and Histopathology of
Keratoconjunctivitis Sicca in the Dog:
A Potential Animal Model for Sjogren's Syndrome. Kaswan RL, Martin CL. National Society to Prevent Blindness, 1982.
Immunopathology of Canine Keratoconjunctivitis
Sicca. Kaswan RL, Martin CL. National Eye Institute, 1981.
quine Recurrent Uveitis: Comparison of the efficacy of Cyclosporine to Conventional
Therapy in an Experimental Rabbit Model.
Kaswan RL, Martin CL, Kaplan HL, Pratt J. Veterinary Medical Experiment Station. June 1985.
A Quantitative Model of Uveitis in the Dog. Kaswan RL, Ward D, Martin CL, Ferguson
D. Foundation of the American
Veterinary Medical Association.
Submitted July 28, 1987.
Modulation of lacrimal secretion by cyclosporine
A. Mircheff AK, Kaswan RL, Warren DW,
Gierow JP. $168,625. Submitted to Sandoz Pharmaceuticals, not
funded 1990.
Research Honors and Awards for Ophthalmic
Cyclosporine
Ralston
Purina Research Award 1991.
University
of Georgia Creative Research Medal 1992.
University
of Georgia Inventor of the Year 1996.
Research Inventions and Patents:
Ophthalmic
treatment by topical administration of cyclosporine. Kaswan RL. US patent
#713,701.
Method of
increasing tear production by topical administration of cyclosporine. Kaswan RL.
US patent #4,839,342.
Ocular
Cyclosporine Composition. Kaswan
RL. US patent # 5,411,952.
Published Refereed Journal Articles:
Immunopathologic Evaluation of 60 Dogs with
Keratoconjunctivitis Sicca. Kaswan RL,
Martin CL, Dawe DL, Chapman WC.
Transaction of American Col Vet Ophthalmol, 207-238, 1983.
Rheumatoid Factor Determination in 50 Dogs with
Keratoconjunctivitis Sicca. Kaswan RL,
Martin CL, Dawe DL. J Am Vet Med Assoc
183:10, 1073-1075, 1983.
Keratoconjunctivitis Sicca: Histologic Study of Nictitating Membrane and Lacrimal Glands from
28 Canine Cases. Kaswan RL, Martin CL,
Chapman WC. Am J Vet Res, 45:1,
112-118, 1984.
Pathology and Immunopathology Associated with KCS in
the Dog. Martin CL, Kaswan RL. Transaction of the German Speaking Small
Animal Practitioners, Frankfurt, 1983.
Keratoconjunctivitis Sicca: Immunological Evaluation of 62 Canine Cases. Kaswan RL, Martin CL, Dawe DL. Am J Vet Res, 46(2) 376-383, 1985.
Surgical Replacement of Third Eyelid Prolapse. Kaswan FL, Martin CL. J Amer Vet Med Assoc, 186(1), 83, 1985.
Modulation of Experimental Uveitis in Rabbits with
Topical Cyclosporine. Kaswan RL, Kaplan
H, Martin CL. Trans Amer Col Vet
Ophthalmol, 16:216-225, 1985.
Distemper-Associated Keratoconjunctivitis Sicca. Martin CL, Kaswan RL. J Amer Anim Hosp Assoc 21:335-359, 1985.
The Normal Ultra structure and Histochemistry of the
Canine Lacrimal Glands. Martin CL,
Munnell M Kaswan RL. Trans of the Amer
Col of Vet Ophthalmol, 17:309-327, 1986.
Topical Application of Cyclosporine: A New Method to Increase Tear Production for
Keratoconjunctivitis Sicca. Kaswan RL,
Salisbury MA. Trans Amer Col Vet
Ophthalmol 18:296:1987.
Intraocular Penetration of Topically Applied Cyclosporine. Kaswan RL, Trans Amer Col Vet Ophthalmol
18:218-238;1987.
Clinical Trails of Ophthalmic Cyclosporine in Chronic
Keratitis. Kaswan RL, Fischer C. Trans Amer Col Vet Ophthalmol
18:276-295;1987.
Comparison of the Efficacy of Unilateral, Bilateral,
and Oral Cyclosporine in Experimental Immunogenic Uveitis in Rabbits. Kaswan RL, Kaplan HJ. Transplantation Proc 20(3) Suppl 4;
1988:149-157.
Intraocular Penetration of Topically Applied
Cyclosporine. Kaswan RL. Transplantation Proc 20(2) Suppl 2;
1988:650-655.
Cyclosporine Eyedrops: A Potential Breakthrough
Treatment for Dry Eye Syndromes. Kaswan
RL. Eye Research: Science Writers
Seminar Research to Prevent Blindness Monograph. Vol 9, 18-20, 1988.
Normal Ultrastructure and Histochemical Characteristics
of Canine Lacrimal Glands. Martin CL,
Munnell J, Kaswan R. Am J Vet Res
49(9):1566-1572;1988.
Blepharoplasty Techniques for Canthus Closure. Kaswan RL, Martin CL, Doran CC. Companion Anim Prac. 2(10:6-8, 1988.
Topically applied cyclosporin for modulation of induced
immunogenic uveitis in rabbits. Kaswan
RL, Kaplan HJ, Martin CL. Amer J Vet
Res, 49(10):1757-1759, 1988.
A new perspective on canine keratoconjunctivitis
sicca: Treatment with ophthalmic
cyclosporine. Vet Clin N Am 20:(3) pp
583-611, 1990.
Review of canine keratoconjunctivitis sicca and
treatment with topical cyclosporine.
Salisbury MA, Kaswan RL. Vet Med
Rep 2:115-127, 1990.
Current
Therapy of Canine Keratoconjunctivitis Sicca and Rationale for Change: Treating the Causal Factors with Topical
Cyclosporine. Kaswan RL, Salisbury,
MA. Veterinary Focus. Vol 1(3);98-104, 1989.
Spontaneous
Canine Keratoconjunctivitis Sicca, A Useful Model for Human KCS: Treatment with Cyclosporine Eyedrops. Kaswan RL, Salisbury MA, Ward DA. Arch Ophthalmol. 107:1210-1216;1989.
Topical Application of Cyclosporine: A New Method to Increase Tear Production for
Keratoconjunctivitis Sicca. Kaswan RL,
Salisbury MA, Ward DA, Martin CL, Ramsey JM, Kemp DT, Fischer CA. J Am Anim Hosp Assoc, 26; 270-274, 1990.
Lacrimomimetic Effects of Cyclosporine: Kaswan RL, Salisbury MA, Mircheff AK, Gierow
JP. Supp Invest Ophth Vis Sci. 1990;
Vol. 31, pg 45.
Prolactin Binding and Prolactin effects on Peroxidase
Release in Rat Exorbital Lacrimal Gland:
Mircheff AK, Warren DW, Wood RL, Kaswan RL, Tororiello PJ, and Lee
LM. Supp Invest Ophth Vis Sci. 1990;
Vol. 31, pg 45.
Keratoconjunctivitis Sicca in Dogs; Treatment with
Topical Cyclosporine: Salisbury MA,
Kaswan RL. Vet Med Report. 1990;
2:115-127.
A New Perspective on Canine Keratoconjunctivitis Sicca;
Treatment with Ophthalmic Cyclosporine:
Kaswan RL, Salisbury MA. Vet
Clin of N Amer: Small Anim Pract. Vol. 20, May 1990.
Effects of Ophthalmic cyclosporine on lacrimal gland
pathology and function in dogs with keratoconjunctivitis sicca. Bounous DL, Carmichael KP, Kaswan RL, et al.
Vet Comp Ophthalmol Vol.5, 1995.
Topical Application of Cyclosporine in the Management
of Keratoconjunctivitis Sicca in Dogs:
Salisbury MA, Kaswan RL, Ward DA, Martin CL, Ramsey JM, Fischer CA. Journ of Amer Anim Hosp Assoc. May/June
1990; Vol. 26.
Immunologic Evaluation of 62 Cases of Canine
Keratoconjunctivitis Sicca. Kaswan
RL. Thesis, UGA Pub., Athens, GA, 1984.
Educational Publications:
Disorders of the tear film. Current Veterinary Therapy
XI, Philadelphia, W.B. Saunders Co. R.
Kaswan
Diseases of
the Lacrimal Apparatus. Kaswan RL,
Martin CL: RW Kirk, ed. Current Veterinary Therapy VIII,
Philadelphia, W.B. Saunders Co., 549-554, 1983.
Latest in Blepharoplasty and Cherry Eye Procedures. Kaswan RL.
Trans Amer Soc Vet Ophthalmol, 1986.
Diseases of the lacrimal apparatus, in press, Saunders
Manual of Small Animal Practice 1991.
R. Kaswan.
Scientific Abstracts:
Intraocular Penetration of Cyclosporine in
Rabbits. Kaswan RL, Tackett RL, Martin
CL, Bartell DE. Invest Ophthalmol Supp. 25, 3:38, 1984.
Comparison of the Efficacy of Unilateral, Bilateral and
Oral Cyclosporine in Experimental Immunogenic Uveitis in Rabbits. Kaswan RL, Martin CL, Kaplan HJ. Trans. 2nd Int. Congress Cyclosporine,
1987;59.
Pharmacokinetics of Ophthalmic Cyclosporine. Kaswan RL, Martin CL, Gardner S. Trans. 2nd Int. Congress Cyclosporine,
11/87, 1987;414.
Topically Applied Cyclosporine: Lacrimomimetic Effects and Reduction of
Leukomas in Dogs with Spontaneous KCS.
Proc Amer Uveitis Society,
4/30/88.
Topically Applied Cyclosporine: Lacrimomimetic Effects and Reduction of
Leukomas in Dogs with Spontaneous KCS.
Kaswan RL. American Uveitis
Society. Longboat Key, FL, 5/1/88.
Topically Applied Cyclosporine: Lacrimomimetic Effects and Reduction of
Leukomas in Dogs with Spontaneous KCS.
Kaswan RL, Salisbury M-A, Ward DL, Martin CL. 8th International Cong of Eye Research, San Francisco, 9/7/88.
Lacrimomimetic effects of cyclosporine. Kaswan RL, Sallisbury MA, Mircheff AK,
Gierow JP. Invest. Ophthalmol & Vis
Sci Supp 31; (4) 1990; 46.
Effects of topical cyclosporine in treating canine
KCS. Kaswan RL, Salisbury MA, Pentlarge
VW, et al. 9th Intern Congress Eye Res,
p. 357, 1990.
Prolactin binding and effects on peroxidase release in
rat exorbital lacrimal gland. Warren
DW, Kaswan RL, Wood RL et al. Invest
Ophthalmol & Vis Sci Supp 31; (4), 1990.
Seminars and Presentations:
Histopathology of the Lacrimal Glands in Canine
Keratoconjunctivitis Sicca. Sept.,
1981. Ophthalmology Seminar Series,
Emory University. Kaswan RL, Martin CL.
Histopathology Lesion in 22 Dogs with
Keratoconjunctivitis Sicca. Oct.,
1981. Amer Col Vet Ophthalmology. Kaswan RL, Martin CL, Chapman WL.
Immunological Evaluation of 62 Dogs with
Keratoconjunctivitis Sicca. Oct. 30,
1983. Am Col Vet Ophthalmol. 14th Annual Meeting. Kaswan RL, Martin CL, Dawe DL.
Immunologic Evaluation of 62 Dogs with
Keratoconjunctivitis Sicca. Southeast
Medical Microbiologists Meeting, Columbia, SC.
1983. Kaswan RL, Martin CL, Dawe
DL.
Intraocular Penetration of Cyclosporine in
Rabbits. Assoc Res Vis Ophthalmol,
Sarasota, FL. April 1983. Kaswan RL, Tackett RL, Martin CL.
Modulation of Experimental Lens-Induced Granulomatous
Endophthalmitis with Cyclosporine.
March 14,1984. Small Animal
Medicine Section Seminar. Kaswan RL.
Intraocular Penetration of Topical Cyclosporine in
Rabbits: Radio Immunoassay of 6 Ocular
Compartments. Sandoz Research
Laboratories, Hanover, NJ. Sept 1984. Kaswan RL.
Modulation of Experimental Lens-Induced Granulomatous
Endophthalmitis with Cyclosporine.
March 29, 1984. Alcon Research
Labs. Kaswan RL.
Modulation of Experimental Uveitis in Rabbits with
Ophthalmic Cyclosporine: Preliminary
Results. Sandoz Research Laboratories,
Hanover, NJ. Sept. 1984. Kaswan RL.
Modulation of Experimental Lens-Induced Uveitis in Rats
with Ophthalmic Cyclosporine:
Preliminary Results. Sandoz
Research Laboratories, Hanover, NJ.
Sept. 1984. Kaswan RL.
Modulation of Experimental Uveitis in Rabbits with
Topical Cyclosporine. Amer Col Vet
Ophthalmol. Sept. 29, 1985. Kaswan RL, Kaplan HJ, Martin CL.
Traumatic Optic Nerve Blindness in the Horse. Amer Col Vet Ophthalmol. Sept. 1985.
Martin CL, Kaswan RL, Chapman WL.
The Latest in Blepharoplasties and "Cherry
Eye" Surgery. Amer Soc Vet
Ophthalmol, Am Vet Med Assoc Atlanta, GA.
July 21, 1986. Kaswan RL.
The Normal Ultrastructure and Histochemistry of Canine
Lacrimal Glands. Amer Col Vet
Ophthalmol. Nov. 1986, New
Orleans. Martin CL, Munnell M, Kaswan
RL.
Ocular Disorders in English Bulldogs. Atlanta Bulldog Club.April 1987. Kaswan RL.
Pharmacokinetics of Ocular Cyclosporine. UGACVM Vet Phys/Pharm Seminar. March 1987.
Kaswan RL.
Experimental Lens-Induced Uveitis in the Rat. UGACVM Vet Pathology Seminar. June 4, 1987. Kaswan RL.
Comparison of Topical and Oral Cyclosporine for the
Prevention of Lens-Induced Uveitis in Rats.
Kaswan RL, Chapman WL, Kaplan HJ, Martin CL. The 2nd International congress on Cyclosporine. Washington DC. Nov. 4, 1987.
Comparison of the Efficacy of Unilateral, Bilateral and
Oral Cyclosporine in Experimental Immunogenic Uveitis in Rabbits. Kaswan RL, Martin CL, Kaplan HL. The 2nd International Congress on
Cyclosporine. Washington DC. Nov. 4, 1987.
Pharmacokinetics of Ophthalmic Cyclosporine. Kaswan RL, Martin CL, Gardner S. The 2nd International Congress of
Cyclosporine. Washington DC. Nov. 4, 1987.
Topical Application of Cyclosporine: A New Method to Increase Tear Production for
Keratoconjunctivitis Sicca. American
College Veterinary of Ophthalmologists, November, 1987, Dallas, Texas.
Intraocular Penetration of Topically Applied
Cyclosporine. American College
Veterinary of Ophthalmologists, November 1987, Dallas, Texas.
Clinical Trials of Ophthalmic Cyclosporine in Chronic
Keratitis. American College of
Veterinary Ophthalmologists, November 1987, Dallas, Texas.
Topical Application of Cyclosporine: A New Method to Increase Tear
Production. UGACVM Internal Medicine
Short Course 1/30/88.
Colloquium on College Teaching: Surviving and Thriving in a Dual Career
Marriage. UGA, Athens, GA, 9/15/88.
Ophthalmic Cyclosporine Use in Chronic Keratitis and
Keratoconjunctivitis Sicca in the Dog.
Kaswan RL. Maryland Veterinary
Medical Association 102 Annual Meeting, Ocean City, MD, 6/26-6/29, 1988.
Keratoconjunctivitis Sicca. RL Kaswan. Ophthalmic
Immunol Symp/Workshop. Am. Uveitis Soc
& Am Col Vet Ophthalmol, Oct 6, 1988, Las Vegas, NV.
Effects of topical cyclosporine in treating canine
KCS. Kaswan RL, Salisbury MA, Pentlarge
VW, Ward DA, Martin CL. Int. Cong Eye
Res, Helsinki, Finland, Aug. 1990.
Lacrimomimetic effects of cyclosporine. Kaswan RL, Salisbury MA, Mircheff AK, Gierow
JP. Assoc Res Vis & Ophthalmol,
Sarasota, FL, May 1990.
Topically applied cyclosporine: Lacrimomimetic effects and reduction of
leukomas in dogs with spontaneous KCS.
8th Int. Cong Eye Res., San Francisco, CA, September 7, 1988.
Topically applied cyclosporine: Lacrimomimetic effects and reduction of
leukomas in dogs with spontaneous KCS.
Kaswan, RL. Amer Uveitis Soc
Meeting, Longboat, FL, May 1, 1988.